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KMID : 0812020070130010038
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Korean Journal of Neurogastroenterology and Motility
2007 Volume.13 No. 1 p.38 ~ p.44
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The Prevalence of Small Intestinal Bacterial Overgrowth in Korean Patients with Irritable Bowel Syndrome
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Paik Chang-Nyol
Choi Myung-Gyu
Nam Kwan-Woo
Kwon Jung-Hyun
Chang Jae-Hyuck
Suh Jung-Pil
Lee In-Seok
Park Jae-Myung
Cho Yu-Kyung
Kim Sang-Woo
Chung In-Sik
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Abstract
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Background/Aims: Small intestinal bacterial overgrowth (SIBO) has been known as one of the important pathophysiologic findings in IBS patients. The purpose of this study is to evaluate the prevalence of SIBO by using a breath test (BT) in Korean patients with IBS.
Methods: Forty nine controls and 39 IBS patients underwent a lactulose BT (LBT) every 15 minute for 180 minutes. At least 7 days later, the glucose BT (GBT) was performed every 10 minute for 120 minutes in 33 (patients: n=13, control: n=20) who had undergone the LBT.
Results: 1) The H2 detected from 45 to 120 minutes in the LBT was significantly higher in the patients with IBS than that for the controls. 2) The prevalence of SIBO with LBT in the IBS patients was significantly higher than that in the controls (48.7% vs. 26.5%, respectively p<0.05). 3) The prevalence of SIBO with LBT in the subgroups of the IBS patients was 44.4% for the IBS-D, 66.7% for the IBS-C and 33.3% for the IBS-A (p=ns). 4) The positive rates of GBT in the control and IBS patients were 20% and 7.1%, respectively (p=ns).
Conclusions: The prevalence of SIBO as diagnosed with using LBT was significantly higher in Korean patients with IBS, suggesting that SIBO was an important etiologic factor of IBS.
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KEYWORD
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Irritable bowel syndrome, Small intestinal bacterial overgrowth, Breath test
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